Reaction Details |
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Target | 7-dehydrocholesterol reductase |
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Ligand | BDBM50396753 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_864350 (CHEMBL2175827) |
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IC50 | 120±n/a nM |
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Citation | Horling, A; Müller, C; Barthel, R; Bracher, F; Imming, P A new class of selective and potent 7-dehydrocholesterol reductase inhibitors. J Med Chem55:7614-22 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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7-dehydrocholesterol reductase |
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Name: | 7-dehydrocholesterol reductase |
Synonyms: | 7-DHC reductase | 7-dehydrocholesterol reductase | Anti-estrogen binding site (AEBS) | D7SR | DHCR7 | DHCR7_HUMAN | Putative sterol reductase SR-2 | Sterol Delta(7)-reductase |
Type: | PROTEIN |
Mol. Mass.: | 54508.42 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_864350 |
Residue: | 475 |
Sequence: | MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMA
CDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHK
FLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPL
LWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFN
GRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHD
HFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDL
FRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCL
ACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF
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BDBM50396753 |
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n/a |
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Name | BDBM50396753 |
Synonyms: | CHEMBL2172349 |
Type | Small organic molecule |
Emp. Form. | C19H23NO3 |
Mol. Mass. | 313.3908 |
SMILES | COc1cccc(CCN2CCc3cc(O)c(OC)cc3C2)c1 |
Structure |
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