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Target7-dehydrocholesterol reductase
LigandBDBM50396753
Substrate/Competitorn/a
Meas. Tech.ChEMBL_864350 (CHEMBL2175827)
IC50 120±n/a nM
Citation Horling, AMüller, CBarthel, RBracher, FImming, P A new class of selective and potent 7-dehydrocholesterol reductase inhibitors. J Med Chem55:7614-22 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
7-dehydrocholesterol reductase
Name:7-dehydrocholesterol reductase
Synonyms:7-DHC reductase | 7-dehydrocholesterol reductase | Anti-estrogen binding site (AEBS) | D7SR | DHCR7 | DHCR7_HUMAN | Putative sterol reductase SR-2 | Sterol Delta(7)-reductase
Type:PROTEIN
Mol. Mass.:54508.42
Organism:Homo sapiens (Human)
Description:ChEMBL_864350
Residue:475
Sequence:
MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMA
CDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHK
FLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPL
LWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFN
GRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHD
HFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDL
FRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCL
ACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF
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  Blast E-value cutoff:
BDBM50396753
n/a
NameBDBM50396753
Synonyms:CHEMBL2172349
TypeSmall organic molecule
Emp. Form.C19H23NO3
Mol. Mass.313.3908
SMILESCOc1cccc(CCN2CCc3cc(O)c(OC)cc3C2)c1
Structure
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