| Reaction Details |
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 | Report a problem with these data |
| Target | 7-dehydrocholesterol reductase |
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| Ligand | BDBM50396754 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_864350 (CHEMBL2175827) |
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| IC50 | 2.3±n/a nM |
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| Citation |  Horling, A; Müller, C; Barthel, R; Bracher, F; Imming, P A new class of selective and potent 7-dehydrocholesterol reductase inhibitors. J Med Chem55:7614-22 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 7-dehydrocholesterol reductase |
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| Name: | 7-dehydrocholesterol reductase |
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| Synonyms: | 7-DHC reductase | 7-dehydrocholesterol reductase | Anti-estrogen binding site (AEBS) | D7SR | DHCR7 | DHCR7_HUMAN | Putative sterol reductase SR-2 | Sterol Delta(7)-reductase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54508.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_864350 |
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| Residue: | 475 |
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| Sequence: | MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMA
CDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHK
FLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPL
LWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFN
GRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHD
HFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDL
FRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCL
ACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF
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| BDBM50396754 |
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| n/a |
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| Name | BDBM50396754 |
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| Synonyms: | CHEMBL2172347 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20ClNO2 |
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| Mol. Mass. | 317.81 |
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| SMILES | COc1cc2CN(CCc3ccc(Cl)cc3)CCc2cc1O |
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| Structure | 
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