| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium/glucose cotransporter 1 |
|---|
| Ligand | BDBM50396768 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_864703 (CHEMBL2174861) |
|---|
| IC50 | 126±n/a nM |
|---|
| Citation |  Ohtake, Y; Sato, T; Kobayashi, T; Nishimoto, M; Taka, N; Takano, K; Yamamoto, K; Ohmori, M; Yamaguchi, M; Takami, K; Yeu, SY; Ahn, KH; Matsuoka, H; Morikawa, K; Suzuki, M; Hagita, H; Ozawa, K; Yamaguchi, K; Kato, M; Ikeda, S Discovery of tofogliflozin, a novel C-arylglucoside with an O-spiroketal ring system, as a highly selective sodium glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes. J Med Chem55:7828-40 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium/glucose cotransporter 1 |
|---|
| Name: | Sodium/glucose cotransporter 1 |
|---|
| Synonyms: | High affinity sodium-glucose cotransporter | NAGT | Na(+)/glucose cotransporter 1 | SC5A1_HUMAN | SGLT1 | SLC5A1 | Sodium-dependent glucose cotransporter 1 (SGLT1) | Sodium/glucose cotransporter 1 | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 73503.78 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P13866 |
|---|
| Residue: | 664 |
|---|
| Sequence: | MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGLWAMFSTNRGTVGGFFL
AGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIY
IKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLA
IFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAI
PTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQR
CLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVG
CTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEK
ELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRV
NEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFIT
IVVISLLTKPIPDVHLYRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKG
IFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCH
AYFA
|
|
|
|---|
| BDBM50396768 |
|---|
| n/a |
|---|
| Name | BDBM50396768 |
|---|
| Synonyms: | CHEMBL2172386 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H28O6 |
|---|
| Mol. Mass. | 400.4648 |
|---|
| SMILES | CCc1ccc(Cc2cc3c(CO[C@]33O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)cc2C)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
