Reaction Details |
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Target | Sodium/glucose cotransporter 2 |
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Ligand | BDBM50396773 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_864704 (CHEMBL2174862) |
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IC50 | 16.8±n/a nM |
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Citation | Ohtake, Y; Sato, T; Kobayashi, T; Nishimoto, M; Taka, N; Takano, K; Yamamoto, K; Ohmori, M; Yamaguchi, M; Takami, K; Yeu, SY; Ahn, KH; Matsuoka, H; Morikawa, K; Suzuki, M; Hagita, H; Ozawa, K; Yamaguchi, K; Kato, M; Ikeda, S Discovery of tofogliflozin, a novel C-arylglucoside with an O-spiroketal ring system, as a highly selective sodium glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes. J Med Chem55:7828-40 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium/glucose cotransporter 2 |
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Name: | Sodium/glucose cotransporter 2 |
Synonyms: | Na(+)/glucose cotransporter 2 | SC5A2_HUMAN | SGLT2 | SLC5A2 | Sodium-Dependent Glucose Cotransporter 2 (SGLT2) | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 2 |
Type: | Protein |
Mol. Mass.: | 72902.00 |
Organism: | Homo sapiens (Human) |
Description: | P31639 |
Residue: | 672 |
Sequence: | MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGR
SMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTA
GVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIA
LLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSL
TVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQR
CLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVG
CSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDR
ELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRV
NEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLL
TLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQ
APAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLM
MAVAVFLWGFYA
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BDBM50396773 |
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n/a |
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Name | BDBM50396773 |
Synonyms: | CHEMBL2172381 |
Type | Small organic molecule |
Emp. Form. | C20H21ClO6 |
Mol. Mass. | 392.83 |
SMILES | OC[C@H]1O[C@]2(OCc3ccc(Cc4ccc(Cl)cc4)cc23)[C@H](O)[C@@H](O)[C@@H]1O |r| |
Structure |
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