| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylinositol 3-kinase catalytic subunit type 3 |
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| Ligand | BDBM50396822 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_861943 (CHEMBL2173747) |
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| IC50 | >10000±n/a nM |
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| Citation |  Norman, MH; Andrews, KL; Bo, YY; Booker, SK; Caenepeel, S; Cee, VJ; D'Angelo, ND; Freeman, DJ; Herberich, BJ; Hong, FT; Jackson, CL; Jiang, J; Lanman, BA; Liu, L; McCarter, JD; Mullady, EL; Nishimura, N; Pettus, LH; Reed, AB; Miguel, TS; Smith, AL; Stec, MM; Tadesse, S; Tasker, A; Aidasani, D; Zhu, X; Subramanian, R; Tamayo, NA; Wang, L; Whittington, DA; Wu, B; Wu, T; Wurz, RP; Yang, K; Zalameda, L; Zhang, N; Hughes, PE Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511. J Med Chem55:7796-816 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylinositol 3-kinase catalytic subunit type 3 |
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| Name: | Phosphatidylinositol 3-kinase catalytic subunit type 3 |
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| Synonyms: | BC033004 | PI3K type 3 | PIK3C3 | PK3C3_HUMAN | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) | Phosphatidylinositol 3-kinase p100 subunit | Phosphoinositide 3-Kinase (PI3K), Vps34 | Phosphoinositide-3-kinase class 3 | PtdIns-3-kinase type 3 | VPS34 | hVPS34 |
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| Type: | Enzyme |
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| Mol. Mass.: | 101551.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human Vps34 protein was expressed as monomeric GST-fusion and purified. |
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| Residue: | 887 |
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| Sequence: | MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVT
CQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAV
PVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTK
AHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDG
DESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIV
SYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDV
EDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKK
DSQSSVSENVSNSGINSAEIDSSQIITSPLPSVSSPPPASKTKEVPDGENLEQDLCTFLI
SRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRS
LLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVK
IRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRK
ENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAE
VMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLN
KEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVK
KVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK
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| BDBM50396822 |
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| n/a |
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| Name | BDBM50396822 |
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| Synonyms: | CHEMBL2170086 | US8772480, 360 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H30FN9O3S |
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| Mol. Mass. | 531.606 |
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| SMILES | COc1ncc(Nc2ncc(cc2-c2nc(C)nc(N)n2)[C@@H](C)N2CCN(C[C@H]2C)S(C)(=O)=O)cc1F |r| |
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| Structure | 
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