| Reaction Details |
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 | Report a problem with these data |
| Target | Histone-lysine N-methyltransferase SUV39H1 |
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| Ligand | BDBM50396978 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_863116 (CHEMBL2175614) |
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| Ki | >100000±n/a nM |
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| Citation |  Anglin, JL; Deng, L; Yao, Y; Cai, G; Liu, Z; Jiang, H; Cheng, G; Chen, P; Dong, S; Song, Y Synthesis and structure-activity relationship investigation of adenosine-containing inhibitors of histone methyltransferase DOT1L. J Med Chem55:8066-74 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone-lysine N-methyltransferase SUV39H1 |
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| Name: | Histone-lysine N-methyltransferase SUV39H1 |
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| Synonyms: | H3-K9-HMTase 1 | Histone H3-K9 methyltransferase 1 | KMT1A | Lysine N-methyltransferase 1A | Position-effect variegation 3-9 homolog | SUV39H | SUV39H1 | SUV91_HUMAN | Su(var)3-9 homolog 1 | Suppressor of variegation 3-9 homolog 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47917.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1473655 |
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| Residue: | 412 |
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| Sequence: | MAENLKGCSVCCKSSWNQLQDLCRLAKLSCPALGISKRNLYDFEVEYLCDYKKIREQEYY
LVKWRGYPDSESTWEPRQNLKCVRILKQFHKDLERELLRRHHRSKTPRHLDPSLANYLVQ
KAKQRRALRRWEQELNAKRSHLGRITVENEVDLDGPPRAFVYINEYRVGEGITLNQVAVG
CECQDCLWAPTGGCCPGASLHKFAYNDQGQVRLRAGLPIYECNSRCRCGYDCPNRVVQKG
IRYDLCIFRTDDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFD
LDYVEDVYTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIRAGEE
LTFDYNMQVDPVDMESTRMDSNFGLAGLPGSPKKRVRIECKCGTESCRKYLF
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| BDBM50396978 |
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| n/a |
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| Name | BDBM50396978 |
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| Synonyms: | CHEMBL2171171 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H44N8O4 |
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| Mol. Mass. | 580.7216 |
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| SMILES | CC(C)N(CCCNC(=O)Nc1ccc(cc1)C(C)(C)C)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCC=C)ncnc12 |r| |
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| Structure | 
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