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TargetProtein arginine N-methyltransferase 1 [11-371]
LigandBDBM50396979
Substrate/Competitorn/a
Meas. Tech.ChEMBL_863117 (CHEMBL2175615)
Ki>100000±n/a nM
Citation Anglin, JLDeng, LYao, YCai, GLiu, ZJiang, HCheng, GChen, PDong, SSong, Y Synthesis and structure-activity relationship investigation of adenosine-containing inhibitors of histone methyltransferase DOT1L. J Med Chem55:8066-74 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein arginine N-methyltransferase 1 [11-371]
Name:Protein arginine N-methyltransferase 1 [11-371]
Synonyms:ANM1_HUMAN | HMT2 | HRMT1L2 | IR1B4 | PRMT1 | Protein arginine N-methyltransferase 1 (PRMT1) | Protein arginine methyltransferase 1 (PRMT1) | Protein-arginine N-methyltransferase 1
Type:Protein
Mol. Mass.:41506.52
Organism:Homo sapiens (Human)
Description:Q99873[11-371]
Residue:361
Sequence:
MENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDE
VRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIV
KANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGL
IFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNAC
LIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYT
HWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRM
R
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  Blast E-value cutoff:
BDBM50396979
n/a
NameBDBM50396979
Synonyms:CHEMBL2171170
TypeSmall organic molecule
Emp. Form.C28H42N8O4
Mol. Mass.554.6843
SMILESCNc1ncnc2n(cnc12)[C@@H]1O[C@H](CN(CCCNC(=O)Nc2ccc(cc2)C(C)(C)C)C(C)C)[C@@H](O)[C@H]1O |r|
Structure
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