Reaction Details |
| Report a problem with these data |
Target | Protein arginine N-methyltransferase 1 [11-371] |
---|
Ligand | BDBM50397031 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_863133 (CHEMBL2175631) |
---|
IC50 | 41700±n/a nM |
---|
Citation | Wang, J; Chen, L; Sinha, SH; Liang, Z; Chai, H; Muniyan, S; Chou, YW; Yang, C; Yan, L; Feng, Y; Li, KK; Lin, MF; Jiang, H; Zheng, YG; Luo, C Pharmacophore-based virtual screening and biological evaluation of small molecule inhibitors for protein arginine methylation. J Med Chem55:7978-87 (2012) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Protein arginine N-methyltransferase 1 [11-371] |
---|
Name: | Protein arginine N-methyltransferase 1 [11-371] |
Synonyms: | ANM1_HUMAN | HMT2 | HRMT1L2 | IR1B4 | PRMT1 | Protein arginine N-methyltransferase 1 (PRMT1) | Protein arginine methyltransferase 1 (PRMT1) | Protein-arginine N-methyltransferase 1 |
Type: | Protein |
Mol. Mass.: | 41506.52 |
Organism: | Homo sapiens (Human) |
Description: | Q99873[11-371] |
Residue: | 361 |
Sequence: | MENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDE
VRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIV
KANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGL
IFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNAC
LIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYT
HWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRM
R
|
|
|
BDBM50397031 |
---|
n/a |
---|
Name | BDBM50397031 |
Synonyms: | CHEMBL2171190 |
Type | Small organic molecule |
Emp. Form. | C23H17N3O5S |
Mol. Mass. | 447.463 |
SMILES | [#8]-c1cc2ccccc2cc1-[#6](=O)-[#7]\[#7]=[#6]-1\[#6]=[#6]/[#6](/[#6]=[#6]-1)=[#7]\[#8]S(=O)(=O)c1ccccc1 |c:18,21| |
Structure |
|