| Reaction Details |
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 | Report a problem with these data |
| Target | Methylated-DNA--protein-cysteine methyltransferase |
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| Ligand | BDBM50397043 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_863278 (CHEMBL2176221) |
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| IC50 | 86±n/a nM |
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| Citation |  Zhu, R; Seow, HA; Baumann, RP; Ishiguro, K; Penketh, PG; Shyam, K; Sartorelli, AC Design of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferase. Bioorg Med Chem Lett22:6242-7 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Methylated-DNA--protein-cysteine methyltransferase |
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| Name: | Methylated-DNA--protein-cysteine methyltransferase |
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| Synonyms: | 6-O-methylguanine-DNA methyltransferase | MGMT | MGMT_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 21651.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_144711 |
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| Residue: | 207 |
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| Sequence: | MDKDCEMKRTTLDSPLGKLELSGCEQGLHEIKLLGKGTSAADAVEVPAPAAVLGGPEPLM
QCTAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTRQVLWKLLKVVKFGEVISYQQLAAL
AGNPKAARAVGGAMRGNPVPILIPCHRVVCSSGAVGNYSGGLAVKEWLLAHEGHRLGKPG
LGGSSGLAGAWLKGAGATSGSPPAGRN
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| BDBM50397043 |
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| n/a |
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| Name | BDBM50397043 |
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| Synonyms: | CHEMBL2171202 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H16N6O2 |
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| Mol. Mass. | 312.3265 |
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| SMILES | CC(=O)NCc1cccc(COc2nc(N)nc3nc[nH]c23)c1 |
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| Structure | 
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