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TargetMethylated-DNA--protein-cysteine methyltransferase
LigandBDBM5491
Substrate/Competitorn/a
Meas. Tech.ChEMBL_863278 (CHEMBL2176221)
IC50 39±n/a nM
Citation Zhu, RSeow, HABaumann, RPIshiguro, KPenketh, PGShyam, KSartorelli, AC Design of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferase. Bioorg Med Chem Lett22:6242-7 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Methylated-DNA--protein-cysteine methyltransferase
Name:Methylated-DNA--protein-cysteine methyltransferase
Synonyms:6-O-methylguanine-DNA methyltransferase | MGMT | MGMT_HUMAN
Type:PROTEIN
Mol. Mass.:21651.27
Organism:Homo sapiens (Human)
Description:ChEMBL_144711
Residue:207
Sequence:
MDKDCEMKRTTLDSPLGKLELSGCEQGLHEIKLLGKGTSAADAVEVPAPAAVLGGPEPLM
QCTAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTRQVLWKLLKVVKFGEVISYQQLAAL
AGNPKAARAVGGAMRGNPVPILIPCHRVVCSSGAVGNYSGGLAVKEWLLAHEGHRLGKPG
LGGSSGLAGAWLKGAGATSGSPPAGRN
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  Blast E-value cutoff:
BDBM5491
n/a
NameBDBM5491
Synonyms:6-(benzyloxy)-9H-purin-2-amine | CHEMBL407874 | O6-Substituted Guanine Deriv. 31
TypeSmall organic molecule
Emp. Form.C12H11N5O
Mol. Mass.241.2486
SMILESNc1nc(OCc2ccccc2)c2[nH]cnc2n1
Structure
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