Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
LigandBDBM50397067
Substrate/Competitorn/a
Meas. Tech.ChEMBL_863498 (CHEMBL2174779)
IC50 45±n/a nM
Citation Banerjee, APatil, SPawar, MYGullapalli, SGupta, PKGandhi, MNBhateja, DKBajpai, MSangana, RRGudi, GSKhairatkar-Joshi, NGharat, LA Imidazopyridazinones as novel PDE7 inhibitors: SAR and in vivo studies in Parkinson's disease model. Bioorg Med Chem Lett22:6286-91 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Name:High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Synonyms:3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1)
Type:Enzyme
Mol. Mass.:55514.96
Organism:Homo sapiens (Human)
Description:Q13946
Residue:482
Sequence:
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTA
LYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRS
SRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSL
HGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW
DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFS
HLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKC
ADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYL
VEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENR
LS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50397067
n/a
NameBDBM50397067
Synonyms:CHEMBL2171429
TypeSmall organic molecule
Emp. Form.C22H24N6O2
Mol. Mass.404.465
SMILESCOc1cc(ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1)-c1cn[nH]c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: