Reaction Details |
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Target | 5-hydroxytryptamine receptor 3A |
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Ligand | BDBM50397291 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_864726 (CHEMBL2174993) |
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Ki | 1.35±n/a nM |
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Citation | Verheij, MH; Thompson, AJ; van Muijlwijk-Koezen, JE; Lummis, SC; Leurs, R; de Esch, IJ Design, synthesis, and structure-activity relationships of highly potent 5-HT3 receptor ligands. J Med Chem55:8603-14 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 3A |
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Name: | 5-hydroxytryptamine receptor 3A |
Synonyms: | 5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3 |
Type: | Protein |
Mol. Mass.: | 55283.27 |
Organism: | Homo sapiens (Human) |
Description: | P46098 |
Residue: | 478 |
Sequence: | MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTT
VSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDI
LINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLH
TIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRR
RPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAI
GTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQ
STSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQ
ELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
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BDBM50397291 |
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n/a |
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Name | BDBM50397291 |
Synonyms: | CHEMBL443764 | VUF-10249 |
Type | Small organic molecule |
Emp. Form. | C13H16N4 |
Mol. Mass. | 228.2929 |
SMILES | CN1CCN(CC1)c1ncc2ccccc2n1 |
Structure |
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