Reaction Details |
| Report a problem with these data |
Target | Histone deacetylase 8 |
---|
Ligand | BDBM50397358 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_864759 (CHEMBL2175141) |
---|
IC50 | 28000±n/a nM |
---|
Citation | Vaidya, AS; Neelarapu, R; Madriaga, A; Bai, H; Mendonca, E; Abdelkarim, H; van Breemen, RB; Blond, SY; Petukhov, PA Novel histone deacetylase 8 ligands without a zinc chelating group: exploring an 'upside-down' binding pose. Bioorg Med Chem Lett22:6621-7 (2012) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Histone deacetylase 8 |
---|
Name: | Histone deacetylase 8 |
Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
Type: | Enzyme |
Mol. Mass.: | 41749.60 |
Organism: | Homo sapiens (Human) |
Description: | Q9BY41 |
Residue: | 377 |
Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
|
|
|
BDBM50397358 |
---|
n/a |
---|
Name | BDBM50397358 |
Synonyms: | CHEMBL2170174 |
Type | Small organic molecule |
Emp. Form. | C30H33N7O5 |
Mol. Mass. | 571.6269 |
SMILES | COc1cc(COc2ccc(NC(=O)CCCCCCC(=O)OCc3ccc(CN=[N+]=[N-])cc3)cc2)cc(c1)N=[N+]=[N-] |
Structure |
|