| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50397363 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_864759 (CHEMBL2175141) |
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| IC50 | 53200±n/a nM |
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| Citation |  Vaidya, AS; Neelarapu, R; Madriaga, A; Bai, H; Mendonca, E; Abdelkarim, H; van Breemen, RB; Blond, SY; Petukhov, PA Novel histone deacetylase 8 ligands without a zinc chelating group: exploring an 'upside-down' binding pose. Bioorg Med Chem Lett22:6621-7 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50397363 |
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| n/a |
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| Name | BDBM50397363 |
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| Synonyms: | CHEMBL2170172 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H37NO4 |
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| Mol. Mass. | 439.587 |
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| SMILES | Cc1cc(C)cc(COc2ccc(NC(=O)CCCCCCC(=O)OC(C)(C)C)cc2)c1 |
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| Structure | 
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