| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H1 receptor |
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| Ligand | BDBM50397482 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_862026 |
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| Ki | 2.51±n/a nM |
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| Citation |  Bahl A; Barton P; Bowers K; Brough S; Evans R; Luckhurst CA; Mochel T; Perry MW; Rigby A; Riley RJ; Sanganee H; Sisson A; Springthorpe B The discovery of CCR3/H1 dual antagonists with reduced hERG risk. Bioorg Med Chem Lett 22:6688-93 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H1 receptor |
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| Name: | Histamine H1 receptor |
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| Synonyms: | H1R | HH1R | HISTAMINE H1 | HRH1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 55808.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay. |
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| Residue: | 487 |
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| Sequence: | MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
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| BDBM50397482 |
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| n/a |
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| Name | BDBM50397482 |
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| Synonyms: | CHEMBL2171013 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H31Cl2N3O4S |
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| Mol. Mass. | 540.502 |
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| SMILES | CN(C(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(Cl)c(Cl)c1)S(=O)(=O)c1ccc(C)cc1 |
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| Structure | 
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