Reaction Details | |||
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Target | Bromodomain-containing protein 4 | ||
Ligand | BDBM50380676 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_873614 (CHEMBL2187903) | ||
IC50 | 501.19±n/a nM | ||
Citation | Seal, J; Lamotte, Y; Donche, F; Bouillot, A; Mirguet, O; Gellibert, F; Nicodeme, E; Krysa, G; Kirilovsky, J; Beinke, S; McCleary, S; Rioja, I; Bamborough, P; Chung, CW; Gordon, L; Lewis, T; Walker, AL; Cutler, L; Lugo, D; Wilson, DM; Witherington, J; Lee, K; Prinjha, RK Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A). Bioorg Med Chem Lett22:2968-72 (2012) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Bromodomain-containing protein 4 | |||
Name: | Bromodomain-containing protein 4 | ||
Synonyms: | BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 (BRD4) | HUNK1 | Protein HUNK1 | ||
Type: | Protein | ||
Mol. Mass.: | 152264.84 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O60885 | ||
Residue: | 1362 | ||
Sequence: |
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BDBM50380676 | |||
n/a | |||
Name | BDBM50380676 | ||
Synonyms: | CHEMBL2017283 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H26N4O3 | ||
Mol. Mass. | 442.5096 | ||
SMILES | COc1cc2c3n(-c4ccccc4C(C)(C)C)c(=O)[nH]c3cnc2cc1-c1c(C)noc1C |(4.94,-26.84,;4.94,-28.38,;6.27,-29.15,;7.6,-28.38,;8.94,-29.14,;10.26,-28.37,;10.57,-26.87,;9.8,-25.54,;8.27,-25.55,;7.49,-24.22,;8.26,-22.87,;9.81,-22.88,;10.57,-24.21,;12.11,-24.21,;12.1,-22.67,;13.6,-24.61,;13.44,-23.43,;12.09,-26.7,;12.85,-25.35,;12.73,-28.09,;11.6,-29.13,;11.61,-30.68,;10.27,-31.45,;8.94,-30.69,;7.61,-31.47,;6.27,-30.7,;4.94,-31.46,;4.9,-33.01,;6.13,-33.94,;3.43,-33.45,;2.55,-32.19,;3.48,-30.96,;3.03,-29.49,)| | ||
Structure |