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TargetCellular tumor antigen p53
LigandBDBM50397775
Substrate/Competitorn/a
Meas. Tech.ChEMBL_874346 (CHEMBL2182644)
IC50 3100±n/a nM
Citation Rew, YSun, DGonzalez-Lopez De Turiso, FBartberger, MDBeck, HPCanon, JChen, AChow, DDeignan, JFox, BMGustin, DHuang, XJiang, MJiao, XJin, LKayser, FKopecky, DJLi, YLo, MCLong, AMMichelsen, KOliner, JDOsgood, TRagains, MSaiki, AYSchneider, SToteva, MYakowec, PYan, XYe, QYu, DZhao, XZhou, JMedina, JCOlson, SH Structure-based design of novel inhibitors of the MDM2-p53 interaction. J Med Chem55:4936-54 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cellular tumor antigen p53
Name:Cellular tumor antigen p53
Synonyms:Antigen NY-CO-13 | CREB-binding protein/p53 | GST-p53 | His6-p53 | P53 | P53_HUMAN | Phosphoprotein p53 | TP53 | Tumor Suppressor p53
Type:fusion protein
Mol. Mass.:43654.73
Organism:Homo sapiens (Human)
Description:The full-length His6-wt-p53 expressed in E. coli was used in assays.
Residue:393
Sequence:
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP
DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK
SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE
RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS
SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP
PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG
GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
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BDBM50397775
n/a
NameBDBM50397775
Synonyms:CHEMBL2177188
TypeSmall organic molecule
Emp. Form.C27H31Cl2N5O3
Mol. Mass.544.473
SMILESCC[C@H](N1[C@@H]([C@H](C[C@H](Cc2nnn[nH]2)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1)C(=O)OC(C)(C)C |r|
Structure
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