Reaction Details | |||
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Target | Lysophosphatidic acid receptor 3 | ||
Ligand | BDBM50398089 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_873924 (CHEMBL2184760) | ||
IC50 | 18600±n/a nM | ||
Citation | Qian, Y; Hamilton, M; Sidduri, A; Gabriel, S; Ren, Y; Peng, R; Kondru, R; Narayanan, A; Truitt, T; Hamid, R; Chen, Y; Zhang, L; Fretland, AJ; Sanchez, RA; Chang, KC; Lucas, M; Schoenfeld, RC; Laine, D; Fuentes, ME; Stevenson, CS; Budd, DC Discovery of highly selective and orally active lysophosphatidic acid receptor-1 antagonists with potent activity on human lung fibroblasts. J Med Chem55:7920-39 (2012) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Lysophosphatidic acid receptor 3 | |||
Name: | Lysophosphatidic acid receptor 3 | ||
Synonyms: | EDG7 | LPA3 | LPAR3 | LPAR3_HUMAN | Lysophosphatidic acid receptor 1/3 | Lysophosphatidic acid receptor 3 (LPAR3) | Lysophosphatidic acid receptor Edg-7 | ||
Type: | Enzyme | ||
Mol. Mass.: | 40149.72 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q9UBY5 | ||
Residue: | 353 | ||
Sequence: |
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BDBM50398089 | |||
n/a | |||
Name | BDBM50398089 | ||
Synonyms: | CHEMBL2182051 | US9321738, 14 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H30N4O4 | ||
Mol. Mass. | 462.5408 | ||
SMILES | C[C@@H](OC(=O)Nc1c(nnn1C)-c1ccc(cc1)C1CCC(CC(O)=O)CC1)c1ccccc1 |r,wD:1.0,(51.8,-50.88,;51.04,-52.22,;49.5,-52.23,;48.72,-50.9,;49.48,-49.56,;47.18,-50.91,;46.4,-49.58,;44.94,-49.14,;44.9,-47.61,;46.34,-47.1,;47.28,-48.32,;48.82,-48.29,;43.57,-49.86,;43.51,-51.4,;42.15,-52.11,;40.85,-51.28,;40.92,-49.74,;42.28,-49.03,;39.48,-51.99,;39.42,-53.53,;38.05,-54.24,;36.75,-53.41,;35.38,-54.12,;34.08,-53.29,;32.71,-54,;34.15,-51.75,;36.82,-51.86,;38.19,-51.16,;51.82,-53.55,;51.06,-54.88,;51.83,-56.21,;53.38,-56.2,;54.14,-54.85,;53.35,-53.52,)| | ||
Structure |