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TargetLysophosphatidic acid receptor 1
LigandBDBM50398106
Substrate/Competitorn/a
Meas. Tech.ChEMBL_873925
IC50 644±n/a nM
Citation Qian YHamilton MSidduri AGabriel SRen YPeng RKondru RNarayanan ATruitt THamid RChen YZhang LFretland AJSanchez RAChang KCLucas MSchoenfeld RCLaine DFuentes MEStevenson CSBudd DC Discovery of highly selective and orally active lysophosphatidic acid receptor-1 antagonists with potent activity on human lung fibroblasts. J Med Chem 55:7920-39 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lysophosphatidic acid receptor 1
Name:Lysophosphatidic acid receptor 1
Synonyms:LPA receptor 1 | LPA-1 | LPAR1 | Lysophosphatidic acid receptor 1 (LPA1) | Lysophosphatidic acid receptor Edg-2
Type:Enzyme
Mol. Mass.:41120.55
Organism:Homo sapiens (Human)
Description:Q92633
Residue:364
Sequence:
MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVC
IFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVST
WLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGA
IPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMS
RHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLA
EFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSND
HSVV
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  Blast E-value cutoff:
BDBM50398106
n/a
NameBDBM50398106
Synonyms:CHEMBL2182058
TypeSmall organic molecule
Emp. Form.C19H17ClFN3O2
Mol. Mass.373.809
SMILESC[C@@H](OC(=O)Nc1c(cnn1C)-c1ccccc1F)c1ccccc1Cl |r|
Structure
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