Reaction Details |
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Target | Microtubule-associated protein tau |
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Ligand | BDBM50398210 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_874179 (CHEMBL2187911) |
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IC50 | 13±n/a nM |
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Citation | Boländer, A; Kieser, D; Voss, C; Bauer, S; Schön, C; Burgold, S; Bittner, T; Hölzer, J; Heyny-von Haußen, R; Mall, G; Goetschy, V; Czech, C; Knust, H; Berger, R; Herms, J; Hilger, I; Schmidt, B Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines as imaging agents for tau fibrils andß-amyloid plaques in Alzheimer's disease models. J Med Chem55:9170-80 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Microtubule-associated protein tau |
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Name: | Microtubule-associated protein tau |
Synonyms: | MAPT | MAPTL | MTBT1 | Microtubule-associated protein tau | Neurofibrillary tangle protein | PHF-tau | Paired helical filament-tau | TAU | TAU_HUMAN | Tau Protein |
Type: | Protein |
Mol. Mass.: | 78928.63 |
Organism: | Homo sapiens (Human) |
Description: | P10636 |
Residue: | 758 |
Sequence: | MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPG
SETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAG
HVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEG
GRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPA
QDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLE
FTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPA
AAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSS
DPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQK
GQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREP
KKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLD
LSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEK
LDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDT
SPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
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BDBM50398210 |
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n/a |
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Name | BDBM50398210 |
Synonyms: | CHEMBL2181039 |
Type | Small organic molecule |
Emp. Form. | C22H20N2O2 |
Mol. Mass. | 344.4064 |
SMILES | COc1ccc(\C=C\c2cnc(\C=C\c3ccc(OC)cc3)cn2)cc1 |
Structure |
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