| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase B-A |
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| Ligand | BDBM14210 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_874448 (CHEMBL2184333) |
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| IC50 | 45±n/a nM |
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| Citation |  Elkins, JM; Santaguida, S; Musacchio, A; Knapp, S Crystal structure of human aurora B in complex with INCENP and VX-680. J Med Chem55:7841-8 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aurora kinase B-A |
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| Name: | Aurora kinase B-A |
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| Synonyms: | AUKBA_XENLA | Aurora/IPL1-related kinase 2-A | Serine/threonine-protein kinase 12-A | Serine/threonine-protein kinase aurora-B-A | XAIRK2-A | airk2-a | aurkb-a | xAurora-B |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41755.74 |
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| Organism: | Xenopus laevis |
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| Description: | ChEMBL_874448 |
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| Residue: | 361 |
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| Sequence: | MSYKENLNPSSYTSKFTTPSSATAAQRVLRKEPYVSTFTTPSDNLLAQRTQLSRITPSAS
SSVPGRVAVSTEMPSQNTALAEMPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMA
LKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYK
ELQKHGRFDEQRSATFMEELADALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVH
APSLRRRTMCGTLDYLPPEMIEGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRR
IVNVDLKFPPFLSDGSKDLISKLLRYHPPQRLPLKGVMEHPWVKANSRRVLPPVYQSTQS
K
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| BDBM14210 |
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| n/a |
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| Name | BDBM14210 |
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| Synonyms: | 4-(4-(N-benzoylamino)anilino)-6-methoxy-7-(3-(1-morpholino)propoxy)-quinazoline | CHEMBL202721 | N-[4-({6-methoxy-7-[3-(morpholin-4-yl)propoxy]quinazolin-4-yl}amino)phenyl]benzamide | ZM447439 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H31N5O4 |
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| Mol. Mass. | 513.5875 |
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| SMILES | COc1cc2c(Nc3ccc(NC(=O)c4ccccc4)cc3)ncnc2cc1OCCCN1CCOCC1 |
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| Structure | 
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