| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase B-A |
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| Ligand | BDBM13534 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_874448 (CHEMBL2184333) |
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| IC50 | 19±n/a nM |
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| Citation |  Elkins, JM; Santaguida, S; Musacchio, A; Knapp, S Crystal structure of human aurora B in complex with INCENP and VX-680. J Med Chem55:7841-8 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aurora kinase B-A |
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| Name: | Aurora kinase B-A |
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| Synonyms: | AUKBA_XENLA | Aurora/IPL1-related kinase 2-A | Serine/threonine-protein kinase 12-A | Serine/threonine-protein kinase aurora-B-A | XAIRK2-A | airk2-a | aurkb-a | xAurora-B |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41755.74 |
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| Organism: | Xenopus laevis |
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| Description: | ChEMBL_874448 |
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| Residue: | 361 |
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| Sequence: | MSYKENLNPSSYTSKFTTPSSATAAQRVLRKEPYVSTFTTPSDNLLAQRTQLSRITPSAS
SSVPGRVAVSTEMPSQNTALAEMPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMA
LKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYK
ELQKHGRFDEQRSATFMEELADALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVH
APSLRRRTMCGTLDYLPPEMIEGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRR
IVNVDLKFPPFLSDGSKDLISKLLRYHPPQRLPLKGVMEHPWVKANSRRVLPPVYQSTQS
K
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| BDBM13534 |
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| n/a |
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| Name | BDBM13534 |
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| Synonyms: | CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]cyclopropanecarboxamide | VX-680 | VX680 | cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2ylsulphanyl]-phenyl}-amide |
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| Type | Small organic molecule |
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| Emp. Form. | C23H28N8OS |
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| Mol. Mass. | 464.586 |
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| SMILES | CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 |
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| Structure | 
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