| Reaction Details |
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 | Report a problem with these data |
| Target | Pteridine reductase 1 |
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| Ligand | BDBM50398389 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_876348 (CHEMBL2185822) |
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| Ki | 100±n/a nM |
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| Citation |  Corona, P; Gibellini, F; Cavalli, A; Saxena, P; Carta, A; Loriga, M; Luciani, R; Paglietti, G; Guerrieri, D; Nerini, E; Gupta, S; Hannaert, V; Michels, PA; Ferrari, S; Costi, PM Structure-based selectivity optimization of piperidine-pteridine derivatives as potent Leishmania pteridine reductase inhibitors. J Med Chem55:8318-29 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pteridine reductase 1 |
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| Name: | Pteridine reductase 1 |
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| Synonyms: | HMTXR | PTR1 | PTR1_LEIMA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30459.34 |
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| Organism: | Leishmania major |
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| Description: | ChEMBL_1470027 |
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| Residue: | 288 |
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| Sequence: | MTAPTVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAI
TVQADLSNVATAPVSGADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLR
NDEDGHEPCVGDREAMETATADLFGSNAIAPYFLIKAFAHRFAGTPAKHRGTNYSIINMV
DAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVWEG
HRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA
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| BDBM50398389 |
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| n/a |
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| Name | BDBM50398389 |
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| Synonyms: | CHEMBL2178601 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H30N8O5 |
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| Mol. Mass. | 522.5563 |
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| SMILES | CCOC(=O)CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)N1CCC(CC1)C(=O)OC |
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| Structure | 
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