Reaction Details | |||
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Target | Corticotropin-releasing factor receptor 1 | ||
Ligand | BDBM50398566 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_873519 (CHEMBL2187021) | ||
IC50 | 46±n/a nM | ||
Citation | Takahashi, Y; Hashizume, M; Shin, K; Terauchi, T; Takeda, K; Hibi, S; Murata-Tai, K; Fujisawa, M; Shikata, K; Taguchi, R; Ino, M; Shibata, H; Yonaga, M Design, synthesis, and structure-activity relationships of novel pyrazolo[5,1-b]thiazole derivatives as potent and orally active corticotropin-releasing factor 1 receptor antagonists. J Med Chem55:8450-63 (2012) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Corticotropin-releasing factor receptor 1 | |||
Name: | Corticotropin-releasing factor receptor 1 | ||
Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 50744.31 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P34998 | ||
Residue: | 444 | ||
Sequence: |
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BDBM50398566 | |||
n/a | |||
Name | BDBM50398566 | ||
Synonyms: | CHEMBL2179196 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H30N4O4S | ||
Mol. Mass. | 470.584 | ||
SMILES | CCCCN(C1CCOCC1)c1c(OC)nn2c(csc12)-c1c(OC)cc(cc1OC)C#N |(24.95,-40.75,;25.72,-42.08,;27.26,-42.07,;28.03,-40.74,;29.57,-40.73,;30.29,-39.37,;31.83,-39.32,;32.55,-37.97,;31.74,-36.66,;30.19,-36.71,;29.46,-38.07,;30.11,-42.18,;29.23,-43.44,;27.69,-43.47,;26.95,-44.82,;30.16,-44.66,;31.62,-44.16,;33.1,-44.6,;33.97,-43.34,;33.04,-42.11,;31.59,-42.62,;33.84,-45.95,;33.05,-47.27,;31.51,-47.24,;30.72,-48.57,;33.8,-48.62,;35.34,-48.64,;36.13,-47.33,;35.38,-45.97,;36.17,-44.66,;37.71,-44.68,;36.09,-49.99,;36.84,-51.33,)| | ||
Structure |