| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 4 |
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| Ligand | BDBM50398598 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_873978 (CHEMBL2185667) |
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| Ki | 0.30±n/a nM |
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| Citation |  Brodney, MA; Johnson, DE; Sawant-Basak, A; Coffman, KJ; Drummond, EM; Hudson, EL; Fisher, KE; Noguchi, H; Waizumi, N; McDowell, LL; Papanikolaou, A; Pettersen, BA; Schmidt, AW; Tseng, E; Stutzman-Engwall, K; Rubitski, DM; Vanase-Frawley, MA; Grimwood, S Identification of multiple 5-HT4 partial agonist clinical candidates for the treatment of Alzheimer's disease. J Med Chem55:9240-54 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 4 |
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| Name: | 5-hydroxytryptamine receptor 4 |
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| Synonyms: | 5-HT-4 | 5-HT4 | 5-HT4L | 5-HT4S | 5-hydroxytryptamine receptor 4 | 5HT4R_RAT | Htr4 | Serotonin (5-HT) receptor | Serotonin 4 (5-HT4) receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 46117.31 |
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| Organism: | RAT |
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| Description: | 5-HT4 HTR4 RAT::Q62758 |
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| Residue: | 406 |
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| Sequence: | MDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIV
SLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYY
AICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSN
STFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRP
QTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWL
GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRD
TVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
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| BDBM50398598 |
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| n/a |
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| Name | BDBM50398598 |
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| Synonyms: | CHEMBL2152922 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H32N2O6 |
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| Mol. Mass. | 432.51 |
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| SMILES | OC1(CN2CCC(COc3noc4cccc(O[C@@H]5CCOC5)c34)CC2)CCOCC1 |r| |
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| Structure | 
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