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TargetSerine/threonine-protein kinase pim-1
LigandBDBM50347750
Substrate/Competitorn/a
Meas. Tech.ChEMBL_875243 (CHEMBL2187125)
IC50 880±n/a nM
Citation Tahtouh, TElkins, JMFilippakopoulos, PSoundararajan, MBurgy, GDurieu, ECochet, CSchmid, RSLo, DCDelhommel, FOberholzer, AEPearl, LHCarreaux, FBazureau, JPKnapp, SMeijer, L Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. J Med Chem55:9312-30 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase pim-1
Name:Serine/threonine-protein kinase pim-1
Synonyms:PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:Protein
Mol. Mass.:35681.82
Organism:Homo sapiens (Human)
Description:P11309
Residue:313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
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  Blast E-value cutoff:
BDBM50347750
n/a
NameBDBM50347750
Synonyms:CHEMBL1802358
TypeSmall organic molecule
Emp. Form.C17H13N3O3
Mol. Mass.307.3034
SMILESO=C1NC(Nc2ccccc2)=NC1=Cc1ccc2OCOc2c1 |w:13.15,c:11|
Structure
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