| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 4 |
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| Ligand | BDBM50292406 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_875248 (CHEMBL2187130) |
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| IC50 | >10000±n/a nM |
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| Citation |  Tahtouh, T; Elkins, JM; Filippakopoulos, P; Soundararajan, M; Burgy, G; Durieu, E; Cochet, C; Schmid, RS; Lo, DC; Delhommel, F; Oberholzer, AE; Pearl, LH; Carreaux, F; Bazureau, JP; Knapp, S; Meijer, L Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. J Med Chem55:9312-30 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity tyrosine-phosphorylation-regulated kinase 4 |
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| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 4 |
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| Synonyms: | DYRK4 | DYRK4_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59629.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1475744 |
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| Residue: | 520 |
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| Sequence: | MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGY
AELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAK
CLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFC
ITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQ
KGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTG
YPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSK
DLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNS
FFPSETRKDKVQGCHHSSRKADEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLP
QLVDAPKKSEAAVGAEVSMTSPGQSKNFSLKNTNVLPPIV
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| BDBM50292406 |
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| n/a |
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| Name | BDBM50292406 |
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| Synonyms: | CHEMBL485053 | leucettamine B |
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| Type | Small organic molecule |
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| Emp. Form. | C12H11N3O3 |
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| Mol. Mass. | 245.234 |
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| SMILES | CN1C(N)=NC(=Cc2ccc3OCOc3c2)C1=O |w:6.6,c:3| |
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| Structure | 
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