Ki Summary

Reaction Details

Report a problem with these data

Target

Dual specificity tyrosine-phosphorylation-regulated kinase 3

Ligand

BDBM50292406

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_875249 (CHEMBL2187131)

IC50

1400±n/a nM

Citation

Tahtouh, T; Elkins, JM; Filippakopoulos, P; Soundararajan, M; Burgy, G; Durieu, E; Cochet, C; Schmid, RS; Lo, DC; Delhommel, F; Oberholzer, AE; Pearl, LH; Carreaux, F; Bazureau, JP; Knapp, S; Meijer, L Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. J Med Chem55:9312-30 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Dual specificity tyrosine-phosphorylation-regulated kinase 3

Name:

Dual specificity tyrosine-phosphorylation-regulated kinase 3

Synonyms:

DYRK3 | DYRK3_HUMAN | Dual-specificity tyrosine-phosphorylation regulated kinase 3

Type:

PROTEIN

Mol. Mass.:

65747.26

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1508026

Residue:

588

Sequence:

MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPR
RLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKS
SDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHG
VIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV
RNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIK
KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC
FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLAC
MMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGS
KDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKR
VVNPASAFQGLGSKLPPVVGIANKLKANLMSETNGSIPLCSVLPKLIS

BDBM50292406

n/a

Name

BDBM50292406

Synonyms:

CHEMBL485053 | leucettamine B

Type

Small organic molecule

Emp. Form.

C12H11N3O3

Mol. Mass.

245.234

SMILES

CN1C(N)=NC(=Cc2ccc3OCOc3c2)C1=O |w:6.6,c:3|

Structure