Ki Summary

Reaction Details

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Target

Dual specificity protein kinase CLK4

Ligand

BDBM100152

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_875429 (CHEMBL2182296)

IC50

50±n/a nM

Citation

Tahtouh, T; Elkins, JM; Filippakopoulos, P; Soundararajan, M; Burgy, G; Durieu, E; Cochet, C; Schmid, RS; Lo, DC; Delhommel, F; Oberholzer, AE; Pearl, LH; Carreaux, F; Bazureau, JP; Knapp, S; Meijer, L Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. J Med Chem55:9312-30 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Dual specificity protein kinase CLK4

Name:

Dual specificity protein kinase CLK4

Synonyms:

CDC-like kinase 4 | CLK4_MOUSE | Clk4

Type:

PROTEIN

Mol. Mass.:

57374.39

Organism:

Mus musculus

Description:

ChEMBL_1502248

Residue:

481

Sequence:

MRHSKRTHCPDWDSRESWGHESYSGSHKRKRRSHSSTQENRHCKPHHQFKDSDCHYLEAR
CLNERDYRDRRYIDEYRNDYCEGYVPRHYHRDVESTYRIHCSKSSVRSRRSSPKRKRNRP
CASHQSHSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHG
MDGLHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFE
LLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYV
VKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDV
WSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPAHMIQKTRKRKYFHHNQLDWDEH
SSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPARRITLDEALQHPFFDLLKR
K

BDBM100152

n/a

Name

BDBM100152

Synonyms:

7-methoxy-1-methyl-9H-beta-carboline;hydrochloride | 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole;hydrochloride | HARMINE | Harmine hydrochloride | MLS002153910 | SMR001233259 | cid_5359389

Type

Small organic molecule

Emp. Form.

C13H12N2O

Mol. Mass.

212.2472

SMILES

COc1ccc2c(c1)[nH]c1c(C)nccc21

Structure