| Reaction Details |
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 | Report a problem with these data |
| Target | Polyamine deacetylase HDAC10 |
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| Ligand | BDBM50398716 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_875949 (CHEMBL2188455) |
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| IC50 | 7570±n/a nM |
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| Citation |  Bergman, JA; Woan, K; Perez-Villarroel, P; Villagra, A; Sotomayor, EM; Kozikowski, AP Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth. J Med Chem55:9891-9 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyamine deacetylase HDAC10 |
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| Name: | Polyamine deacetylase HDAC10 |
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| Synonyms: | HD10 | HDA10_HUMAN | HDAC10 | Histone deacetylase | Histone deacetylase 10 | Human HDAC10 |
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| Type: | Chromatin regulator; hydrolase; repressor |
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| Mol. Mass.: | 71431.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q969S8 |
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| Residue: | 669 |
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| Sequence: | MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL
GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG
AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ
YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA
AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV
LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ
DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD
ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA
ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS
MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL
AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM
LQCHPHLVA
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| BDBM50398716 |
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| n/a |
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| Name | BDBM50398716 |
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| Synonyms: | CHEMBL2179618 | US10227295, Compound 5g | US9409858, 5g | US9751832, Compound 5g | US9956192, Compound 5g |
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| Type | Small organic molecule |
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| Emp. Form. | C19H23N3O3 |
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| Mol. Mass. | 341.4042 |
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| SMILES | CCCCN(Cc1ccc(cc1)C(=O)NO)C(=O)Nc1ccccc1 |
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| Structure | 
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