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TargetGlutamate carboxypeptidase II
LigandBDBM50102258
Substrate/Competitorn/a
Meas. Tech.ChEMBL_873321
Ki 8±n/a nM
Citation Graham KLesche RGromov AVBöhnke NSchäfer MHassfeld JDinkelborg LKettschau G Radiofluorinated derivatives of 2-(phosphonomethyl)pentanedioic acid as inhibitors of prostate specific membrane antigen (PSMA) for the imaging of prostate cancer. J Med Chem 55:9510-20 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glutamate carboxypeptidase II
Name:Glutamate carboxypeptidase II
Synonyms:FGCP | Folate hydrolase 1 | Folylpoly-gamma-glutamate carboxypeptidase | Glutamate carboxypeptidase 2 | Membrane glutamate carboxypeptidase | N-acetylated-alpha-linked acidic dipeptidase I | NAALADase I | PSM | PSMA | Prostate-specific membrane antigen | Pteroylpoly-gamma-glutamate carboxypeptidase | mGCP
Type:PROTEIN
Mol. Mass.:84333.66
Organism:Homo sapiens (Human)
Description:ChEMBL_1497035
Residue:750
Sequence:
MWNLLHETDSAVATARRPRWLCAGALVLAGGFFLLGFLFGWFIKSSNEATNITPKHNMKA
FLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLLSYP
NKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDLVYVNYA
RTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADYFAPGVK
SYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIPVHPIGYY
DAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIG
TLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEGWRPRRTILFAS
WDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVHNLTKE
LKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKN
WETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDY
AVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIV
LRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVD
PSKAWGEVKRQIYVAAFTVQAAAETLSEVA
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  Blast E-value cutoff:
BDBM50102258
n/a
NameBDBM50102258
Synonyms:(S)-2-[3-((S)-3-Carboxy-1-carboxy-propyl)-ureido]-pentanedioic acid | 2-[3-(1,3-Dicarboxy-propyl)-ureido]-pentanedioic acid | CHEMBL46005
TypeSmall organic molecule
Emp. Form.C11H16N2O9
Mol. Mass.320.2527
SMILESOC(=O)CC[C@H](NC(=O)N[C@@H](CCC(O)=O)C(O)=O)C(O)=O
Structure
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