| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glutamate carboxypeptidase 2 |
|---|
| Ligand | BDBM50102258 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_873321 (CHEMBL2185174) |
|---|
| Ki | 8±n/a nM |
|---|
| Citation |  Graham, K; Lesche, R; Gromov, AV; Böhnke, N; Schäfer, M; Hassfeld, J; Dinkelborg, L; Kettschau, G Radiofluorinated derivatives of 2-(phosphonomethyl)pentanedioic acid as inhibitors of prostate specific membrane antigen (PSMA) for the imaging of prostate cancer. J Med Chem55:9510-20 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glutamate carboxypeptidase 2 |
|---|
| Name: | Glutamate carboxypeptidase 2 |
|---|
| Synonyms: | FGCP | FOLH | FOLH1 | FOLH1_HUMAN | Folate hydrolase 1 | Folylpoly-gamma-glutamate carboxypeptidase | Glutamate carboxypeptidase 2 | Glutamate carboxypeptidase II | Membrane glutamate carboxypeptidase | N-acetylated-alpha-linked acidic dipeptidase I | NAALAD1 | NAALADase I | PSM | PSMA | Prostate-specific membrane antigen | Pteroylpoly-gamma-glutamate carboxypeptidase | mGCP |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 84333.66 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1497035 |
|---|
| Residue: | 750 |
|---|
| Sequence: | MWNLLHETDSAVATARRPRWLCAGALVLAGGFFLLGFLFGWFIKSSNEATNITPKHNMKA
FLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLLSYP
NKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDLVYVNYA
RTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADYFAPGVK
SYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIPVHPIGYY
DAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIG
TLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEGWRPRRTILFAS
WDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVHNLTKE
LKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKN
WETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDY
AVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIV
LRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVD
PSKAWGEVKRQIYVAAFTVQAAAETLSEVA
|
|
|
|---|
| BDBM50102258 |
|---|
| n/a |
|---|
| Name | BDBM50102258 |
|---|
| Synonyms: | (S)-2-[3-((S)-3-Carboxy-1-carboxy-propyl)-ureido]-pentanedioic acid | 2-[3-(1,3-Dicarboxy-propyl)-ureido]-pentanedioic acid | CHEMBL46005 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H16N2O9 |
|---|
| Mol. Mass. | 320.2527 |
|---|
| SMILES | OC(=O)CC[C@H](NC(=O)N[C@@H](CCC(O)=O)C(O)=O)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
