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TargetHistone deacetylase 8
LigandBDBM50399005
Substrate/Competitorn/a
Meas. Tech.ChEMBL_876031 (CHEMBL2182322)
IC50>30000±n/a nM
Citation Wong, JCTang, GWu, XLiang, CZhang, ZGuo, LPeng, ZZhang, WLin, XWang, ZMei, JChen, JPan, SZhang, NLiu, YZhou, MFeng, LZhao, WLi, SZhang, CZhang, MRong, YJin, TGZhang, XRen, SJi, YZhao, RShe, JRen, YXu, CChen, DCai, JShan, SPan, DNing, ZLu, XChen, THe, YChen, L Pharmacokinetic optimization of class-selective histone deacetylase inhibitors and identification of associated candidate predictive biomarkers of hepatocellular carcinoma tumor response. J Med Chem55:8903-25 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histone deacetylase 8
Name:Histone deacetylase 8
Synonyms:HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:Enzyme
Mol. Mass.:41749.60
Organism:Homo sapiens (Human)
Description:Q9BY41
Residue:377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50399005
n/a
NameBDBM50399005
Synonyms:CHEMBL2177588
TypeSmall organic molecule
Emp. Form.C27H27ClN4O2
Mol. Mass.474.982
SMILESCN1C[C@H]([C@@H](C1)c1ccc(\C=C\C(=O)Nc2ccccc2N)cc1)C(=O)Nc1ccc(Cl)cc1 |r|
Structure
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