| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 3 |
|---|
| Ligand | BDBM50399005 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_874013 (CHEMBL2186138) |
|---|
| IC50 | 200±n/a nM |
|---|
| Citation |  Wong, JC; Tang, G; Wu, X; Liang, C; Zhang, Z; Guo, L; Peng, Z; Zhang, W; Lin, X; Wang, Z; Mei, J; Chen, J; Pan, S; Zhang, N; Liu, Y; Zhou, M; Feng, L; Zhao, W; Li, S; Zhang, C; Zhang, M; Rong, Y; Jin, TG; Zhang, X; Ren, S; Ji, Y; Zhao, R; She, J; Ren, Y; Xu, C; Chen, D; Cai, J; Shan, S; Pan, D; Ning, Z; Lu, X; Chen, T; He, Y; Chen, L Pharmacokinetic optimization of class-selective histone deacetylase inhibitors and identification of associated candidate predictive biomarkers of hepatocellular carcinoma tumor response. J Med Chem55:8903-25 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 3 |
|---|
| Name: | Histone deacetylase 3 |
|---|
| Synonyms: | HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 48829.55 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O15379 |
|---|
| Residue: | 428 |
|---|
| Sequence: | MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKESDVEI
|
|
|
|---|
| BDBM50399005 |
|---|
| n/a |
|---|
| Name | BDBM50399005 |
|---|
| Synonyms: | CHEMBL2177588 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H27ClN4O2 |
|---|
| Mol. Mass. | 474.982 |
|---|
| SMILES | CN1C[C@H]([C@@H](C1)c1ccc(\C=C\C(=O)Nc2ccccc2N)cc1)C(=O)Nc1ccc(Cl)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
