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Target11-beta-hydroxysteroid dehydrogenase 1
LigandBDBM50399338
Substrate/Competitorn/a
Meas. Tech.ChEMBL_877632 (CHEMBL2184996)
IC50 9±n/a nM
Citation Scott, JSdeSchoolmeester, JKilgour, EMayers, RMPacker, MJHargreaves, DGerhardt, SOgg, DJRees, ASelmi, NStocker, ASwales, JGWhittamore, PR Novel acidic 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329). J Med Chem55:10136-47 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
11-beta-hydroxysteroid dehydrogenase 1
Name:11-beta-hydroxysteroid dehydrogenase 1
Synonyms:11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:Enzyme
Mol. Mass.:32409.16
Organism:Homo sapiens (Human)
Description:P28845
Residue:292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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  Blast E-value cutoff:
BDBM50399338
n/a
NameBDBM50399338
Synonyms:CHEMBL2177606
TypeSmall organic molecule
Emp. Form.C26H31N3O3
Mol. Mass.433.5426
SMILESOC(=O)c1ccc(cc1)-n1ncc(C(=O)NC2C3CC4CC(C3)CC2C4)c1C1CCCC1 |TLB:15:16:18.25.19:23.21.22,25:24:22:18.19.20,THB:15:16:22:18.19.20,25:19:16.24.23:22,20:19:16:23.21.22,20:21:16:18.25.19,(33.58,-8.41,;35.11,-8.57,;35.73,-9.98,;36.01,-7.32,;35.39,-5.91,;36.3,-4.67,;37.83,-4.84,;38.45,-6.23,;37.55,-7.48,;38.73,-3.59,;38.26,-2.13,;39.5,-1.22,;40.75,-2.13,;42.22,-1.66,;42.54,-.15,;43.36,-2.69,;44.83,-2.21,;46.02,-.94,;47.35,-1.43,;48.75,-1.08,;48.76,.46,;47.36,1.03,;46.02,.56,;46.32,-.2,;46.33,-1.79,;47.73,-2.36,;40.27,-3.59,;41.18,-4.84,;40.7,-6.3,;41.94,-7.21,;43.19,-6.3,;42.71,-4.84,)|
Structure
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