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TargetNuclear receptor subfamily 1 group I member 2
LigandBDBM50399544
Substrate/Competitorn/a
Meas. Tech.ChEMBL_878388 (CHEMBL2186894)
EC50 430±n/a nM
Citation Shao, PPYe, FChakravarty, PKVarughese, DJHerrington, JBDai, GBugianesi, RMHaedo, RJSwensen, AMWarren, VASmith, MMGarcia, MLMcManus, OBLyons, KALi, XGreen, MJochnowitz, NMcGowan, EMistry, SSun, SYAbbadie, CKaczorowski, GJDuffy, JL Aminopiperidine sulfonamide Cav2.2 channel inhibitors for the treatment of chronic pain. J Med Chem55:9847-55 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Nuclear receptor subfamily 1 group I member 2
Name:Nuclear receptor subfamily 1 group I member 2
Synonyms:NR1I2 | NR1I2_HUMAN | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1
Type:Nuclear receptor
Mol. Mass.:49774.77
Organism:Homo sapiens (Human)
Description:O75469
Residue:434
Sequence:
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG
CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE
RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSS
GCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLL
PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE
CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR
VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF
ATPLMQELFGITGS
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  Blast E-value cutoff:
BDBM50399544
n/a
NameBDBM50399544
Synonyms:CHEMBL2180905
TypeSmall organic molecule
Emp. Form.C23H24F4N2O5S2
Mol. Mass.548.571
SMILESCS(=O)(=O)c1ccc(F)cc1C(=O)N1CCC(CC1)N(C1CC1)S(=O)(=O)c1cccc(c1)C(F)(F)F
Structure
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