Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 4

Ligand

BDBM50399621

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_878535 (CHEMBL2188200)

0.23±n/a nM

Citation

Dubost, E; Dumas, N; Fossey, C; Magnelli, R; Butt-Gueulle, S; Ballandonne, C; Caignard, DH; Dulin, F; Sopkova de-Oliveira Santos, J; Millet, P; Charnay, Y; Rault, S; Cailly, T; Fabis, F Synthesis and structure-affinity relationships of selective high-affinity 5-HT(4) receptor antagonists: application to the design of new potential single photon emission computed tomography tracers. J Med Chem55:9693-707 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 4

Name:

5-hydroxytryptamine receptor 4

Synonyms:

5-HT-4 | 5-HT4 | 5-HT4S | 5-HT4a | 5-HT4b | 5-HT4c | 5-HT4d | 5-HT4hb | 5-hydroxytryptamine receptor 4 | 5-hydroxytryptamine receptor 4 (5-HT4) | 5HT4R_HUMAN | HTR4 | Serotonin (5-HT) receptor | Serotonin (5-HT3) receptor | Serotonin 4 (5-HT4) receptor | Serotonin Receptor 4

Type:

Enzyme

Mol. Mass.:

43767.54

Organism:

Homo sapiens (Human)

Description:

Q13639

Residue:

388

Sequence:

MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV
SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY
AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN
STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP
QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL
GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRD
AVECGGQWESQCHPPATSPLVAAQPSDT

BDBM50399621

n/a

Name

BDBM50399621

Synonyms:

CHEMBL2181166

Type

Small organic molecule

Emp. Form.

C27H27FIN3O

Mol. Mass.

555.4257

SMILES

Fc1cccc2c1nc(OCC1CCN(CCCc3ccc(I)cc3)CC1)c1cccnc21

Structure