| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 2 |
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| Ligand | BDBM50397360 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_878901 (CHEMBL2185052) |
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| IC50 | >100000±n/a nM |
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| Citation |  Suzuki, T; Ota, Y; Ri, M; Bando, M; Gotoh, A; Itoh, Y; Tsumoto, H; Tatum, PR; Mizukami, T; Nakagawa, H; Iida, S; Ueda, R; Shirahige, K; Miyata, N Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries. J Med Chem55:9562-75 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 2 |
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| Name: | Histone deacetylase 2 |
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| Synonyms: | Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2 |
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| Type: | Chromatin regulator; hydrolase; repressor |
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| Mol. Mass.: | 55356.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92769 |
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| Residue: | 488 |
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| Sequence: | MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
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| BDBM50397360 |
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| n/a |
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| Name | BDBM50397360 |
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| Synonyms: | CHEMBL2170177 | US10188756, Compound CN110 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16N2O3 |
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| Mol. Mass. | 296.3205 |
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| SMILES | COc1ccc(Cn2ccc3ccc(cc23)C(=O)NO)cc1 |
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| Structure | 
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