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TargetDiacylglycerol O-acyltransferase 1
LigandBDBM50399687
Substrate/Competitorn/a
Meas. Tech.ChEMBL_876789 (CHEMBL2183606)
IC50 120±n/a nM
Citation Barlind, JG; Bauer, UA; Birch, AM; Birtles, S; Buckett, LK; Butlin, RJ; Davies, RD; Eriksson, JW; Hammond, CD; Hovland, R; Johannesson, P; Johansson, MJ; Kemmitt, PD; Lindmark, BT; Morentin Gutierrez, P; Noeske, TA; Nordin, A; O'Donnell, CJ; Petersson, AU; Redzic, A; Turnbull, AV; Vinblad, J Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687). J Med Chem55:10610-29 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Diacylglycerol O-acyltransferase 1
Name:Diacylglycerol O-acyltransferase 1
Synonyms:ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:Protein
Mol. Mass.:55297.82
Organism:Homo sapiens (Human)
Description:O75907
Residue:488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
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BDBM50399687
n/a
NameBDBM50399687
Synonyms:CHEMBL2178941
TypeSmall organic molecule
Emp. Form.C22H27N3O3
Mol. Mass.381.4681
SMILESCc1nc(C)c(nc1C(N)=O)-c1ccc(cc1)[C@H]1CC[C@H](CCC(O)=O)CC1 |r,wU:17.18,wD:20.22,(43.96,-49.43,;45.3,-48.66,;46.64,-49.43,;47.97,-48.65,;49.3,-49.42,;47.97,-47.12,;46.63,-46.35,;45.3,-47.11,;43.97,-46.34,;42.63,-47.11,;43.97,-44.8,;49.3,-46.35,;50.63,-47.12,;51.97,-46.35,;51.96,-44.8,;50.63,-44.04,;49.3,-44.81,;53.3,-44.03,;53.29,-42.49,;54.63,-41.72,;55.96,-42.49,;57.3,-41.72,;58.63,-42.49,;59.96,-41.72,;61.3,-42.49,;59.96,-40.18,;55.96,-44.03,;54.63,-44.8,)|
Structure
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