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TargetDiacylglycerol O-acyltransferase 1 (DGAT1)
LigandBDBM50399690
Substrate/Competitorn/a
Meas. Tech.ChEMBL_876789
IC50 1100±n/a nM
Citation Barlind JGBauer UABirch AMBirtles SBuckett LKButlin RJDavies RDEriksson JWHammond CDHovland RJohannesson PJohansson MJKemmitt PDLindmark BTMorentin Gutierrez PNoeske TANordin AO'Donnell CJPetersson AURedzic ATurnbull AVVinblad J Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687). J Med Chem 55:10610-29 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Diacylglycerol O-acyltransferase 1 (DGAT1)
Name:Diacylglycerol O-acyltransferase 1 (DGAT1)
Synonyms:ACAT-related gene product 1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diglyceride acyltransferase
Type:Protein
Mol. Mass.:55297.82
Organism:Homo sapiens (Human)
Description:O75907
Residue:488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
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  Blast E-value cutoff:
BDBM50399690
n/a
NameBDBM50399690
Synonyms:CHEMBL2178938
TypeSmall organic molecule
Emp. Form.C23H28N4O4
Mol. Mass.424.4928
SMILESCC(C)(NC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1cncc(n1)C(N)=O)C(O)=O |r,wU:10.13,wD:7.6,(75.46,-31.72,;76.24,-30.39,;77,-31.72,;74.9,-29.62,;73.57,-30.39,;73.57,-31.93,;72.24,-29.62,;70.9,-30.39,;69.57,-29.62,;68.23,-30.39,;68.24,-31.93,;69.57,-32.7,;70.9,-31.93,;66.9,-32.7,;66.91,-34.25,;65.57,-35.02,;64.24,-34.25,;64.24,-32.71,;65.57,-31.93,;62.91,-35.02,;62.91,-36.55,;61.58,-37.32,;60.24,-36.55,;60.24,-35.01,;61.57,-34.24,;58.91,-34.24,;57.57,-35.01,;58.91,-32.7,;77.57,-29.62,;78.91,-30.39,;77.57,-28.08,)|
Structure
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