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TargetDiacylglycerol O-acyltransferase 1 (DGAT1)
LigandBDBM50399694
Substrate/Competitorn/a
Meas. Tech.ChEMBL_876789
IC50 1200±n/a nM
Citation Barlind JGBauer UABirch AMBirtles SBuckett LKButlin RJDavies RDEriksson JWHammond CDHovland RJohannesson PJohansson MJKemmitt PDLindmark BTMorentin Gutierrez PNoeske TANordin AO'Donnell CJPetersson AURedzic ATurnbull AVVinblad J Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687). J Med Chem 55:10610-29 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Diacylglycerol O-acyltransferase 1 (DGAT1)
Name:Diacylglycerol O-acyltransferase 1 (DGAT1)
Synonyms:ACAT-related gene product 1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diglyceride acyltransferase
Type:Protein
Mol. Mass.:55297.82
Organism:Homo sapiens (Human)
Description:O75907
Residue:488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
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  Blast E-value cutoff:
BDBM50399694
n/a
NameBDBM50399694
Synonyms:CHEMBL2178934
TypeSmall organic molecule
Emp. Form.C19H23N3O2
Mol. Mass.325.4048
SMILESNC(=O)c1cncc(n1)-c1ccc(cc1)[C@H]1CC[C@H](CCO)CC1 |r,wU:15.16,wD:18.20,(57.84,-21.32,;59.18,-20.56,;59.18,-19.02,;60.51,-21.33,;60.51,-22.87,;61.85,-23.64,;63.18,-22.87,;63.18,-21.33,;61.84,-20.56,;64.51,-20.56,;65.84,-21.34,;67.18,-20.56,;67.17,-19.01,;65.84,-18.25,;64.51,-19.02,;68.51,-18.24,;68.5,-16.71,;69.83,-15.93,;71.17,-16.7,;72.5,-15.93,;73.84,-16.7,;75.17,-15.93,;71.17,-18.24,;69.84,-19.01,)|
Structure
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