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TargetDiacylglycerol O-acyltransferase 1 (DGAT1)
LigandBDBM50399701
Substrate/Competitorn/a
Meas. Tech.ChEMBL_876789
IC50>10000±n/a nM
Citation Barlind JGBauer UABirch AMBirtles SBuckett LKButlin RJDavies RDEriksson JWHammond CDHovland RJohannesson PJohansson MJKemmitt PDLindmark BTMorentin Gutierrez PNoeske TANordin AO'Donnell CJPetersson AURedzic ATurnbull AVVinblad J Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687). J Med Chem 55:10610-29 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Diacylglycerol O-acyltransferase 1 (DGAT1)
Name:Diacylglycerol O-acyltransferase 1 (DGAT1)
Synonyms:ACAT-related gene product 1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diglyceride acyltransferase
Type:Protein
Mol. Mass.:55297.82
Organism:Homo sapiens (Human)
Description:O75907
Residue:488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50399701
n/a
NameBDBM50399701
Synonyms:CHEMBL2178390
TypeSmall organic molecule
Emp. Form.C23H29N3O3
Mol. Mass.395.4947
SMILESCC(C)c1nc(C)c(nc1C(N)=O)-c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1 |r,wU:19.20,wD:22.24,(2.81,-9.81,;4.14,-10.58,;4.14,-12.12,;5.48,-9.81,;6.82,-10.58,;8.15,-9.81,;9.48,-10.57,;8.15,-8.27,;6.81,-7.5,;5.48,-8.26,;4.15,-7.49,;2.81,-8.26,;4.15,-5.95,;9.48,-7.5,;10.81,-8.27,;12.15,-7.5,;12.14,-5.95,;10.81,-5.19,;9.48,-5.96,;13.48,-5.18,;13.47,-3.64,;14.8,-2.87,;16.14,-3.64,;17.47,-2.87,;18.81,-3.64,;20.14,-2.87,;18.81,-5.18,;16.14,-5.18,;14.81,-5.95,)|
Structure
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