Reaction Details |
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Target | Chloroquine resistance transporter |
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Ligand | BDBM50399930 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_877808 (CHEMBL2187303) |
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IC50 | 228000±n/a nM |
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Citation | Gemma, S; Camodeca, C; Brindisi, M; Brogi, S; Kukreja, G; Kunjir, S; Gabellieri, E; Lucantoni, L; Habluetzel, A; Taramelli, D; Basilico, N; Gualdani, R; Tadini-Buoninsegni, F; Bartolommei, G; Moncelli, MR; Martin, RE; Summers, RL; Lamponi, S; Savini, L; Fiorini, I; Valoti, M; Novellino, E; Campiani, G; Butini, S Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents. J Med Chem55:10387-404 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Chloroquine resistance transporter |
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Name: | Chloroquine resistance transporter |
Synonyms: | CRT | CRT_PLAFA | PfCRT |
Type: | PROTEIN |
Mol. Mass.: | 48687.29 |
Organism: | Plasmodium falciparum |
Description: | ChEMBL_1364181 |
Residue: | 424 |
Sequence: | MKFASKKNNQKNSSKNDERYRELDNLVQEGNGSRLGGGSCLGKCAHVFKLIFKEIKDNIF
IYILSIIYLSVCVMNKIFAKRTLNKIGNYSFVTSETHNFICMIMFFIVYSLFGNKKGNSK
ERHRSFNLQFFAISMLDACSVILAFIGLTRTTGNIQSFVLQLSIPINMFFCFLILRYRYH
LYNYLGAVIIVVTIALVEMKLSFETQEENSIIFNLVLISALIPVCFSNMTREIVFKKYKI
DILRLNAMVSFFQLFTSCLILPVYTLPFLKQLHLPYNEIWTNIKNGFACLFLGRNTVVEN
CGLGMAKLCDDCDGAWKTFALFSFFNICDNLITSYIIDKFSTMTYTIVSCIQGPAIAIAY
YFKFLAGDVVREPRLLDFVTLFGYLFGSIIYRVGNIILERKKMRNEENEDSEGELTNVDS
IITQ
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BDBM50399930 |
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n/a |
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Name | BDBM50399930 |
Synonyms: | CHEMBL2181208 |
Type | Small organic molecule |
Emp. Form. | C24H21ClN4 |
Mol. Mass. | 400.903 |
SMILES | Clc1ccc2c(Nc3ccc4CN(Cc5ccccc5)CNc4c3)ccnc2c1 |
Structure |
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