Reaction Details |
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Target | Glutaminase liver isoform, mitochondrial |
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Ligand | BDBM108460 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_877992 (CHEMBL2189058) |
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IC50 | 5500±n/a nM |
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Citation | Shukla, K; Ferraris, DV; Thomas, AG; Stathis, M; Duvall, B; Delahanty, G; Alt, J; Rais, R; Rojas, C; Gao, P; Xiang, Y; Dang, CV; Slusher, BS; Tsukamoto, T Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors. J Med Chem55:10551-63 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glutaminase liver isoform, mitochondrial |
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Name: | Glutaminase liver isoform, mitochondrial |
Synonyms: | GLS | GLSL_MOUSE | Gls2 | Kiaa4146 | L-glutaminase | L-glutamine amidohydrolase |
Type: | PROTEIN |
Mol. Mass.: | 66377.32 |
Organism: | Mus musculus |
Description: | ChEMBL_877992 |
Residue: | 602 |
Sequence: | MRSMRALQNALSRAGSHGRRGGWGHPSRGPLLGRGVRYYLGEAAAQGRGTPHSHQPQHSD
HDASHSGMLPRLGDLLFYTIAEGQERIPIHKFTTALKATGLQTSDPRLQDCMSKMQRMVQ
ESSSGGLLDRELFQKCVSSNIVLLTQAFRKKFVIPDFEEFTGHVDRIFEDAKEPTGGKVA
AYIPHLAKSNPDLWGVSLCTVDGQRHSVGHTKIPFCLQSCVKPLTYAISVSTLGTDYVHK
FVGKEPSGLRYNKLSLNEEGIPHNPMVNAGAIVVSSLIKMDCNKAEKFDFVLQYLNKMAG
NEFMGFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESG
SVMAATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGA
ILLVVPNVMGMMCLSPPLDKLGNSQRGINFCQKLVSLFNFHNYDNLRHCARKLDPRREGG
EVRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIE
ACKVNPFVKDRWGNIPLDDAVQFNHLEVVKLLQDYHDSYLLSETQAEAAAETLSKENLES
MV
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BDBM108460 |
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n/a |
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Name | BDBM108460 |
Synonyms: | CHEMBL2178393 | US11191732, Example 1 | US8604016, 17 | US9938267, Cmpd ID 17 |
Type | Small organic molecule |
Emp. Form. | C16H18N6OS3 |
Mol. Mass. | 406.549 |
SMILES | Nc1nnc(CCSCCc2nnc(NC(=O)Cc3ccccc3)s2)s1 |
Structure |
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