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TargetGlutaminase liver isoform, mitochondrial
LigandBDBM108460
Substrate/Competitorn/a
Meas. Tech.ChEMBL_877992 (CHEMBL2189058)
IC50 5500±n/a nM
Citation Shukla, KFerraris, DVThomas, AGStathis, MDuvall, BDelahanty, GAlt, JRais, RRojas, CGao, PXiang, YDang, CVSlusher, BSTsukamoto, T Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors. J Med Chem55:10551-63 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glutaminase liver isoform, mitochondrial
Name:Glutaminase liver isoform, mitochondrial
Synonyms:GLS | GLSL_MOUSE | Gls2 | Kiaa4146 | L-glutaminase | L-glutamine amidohydrolase
Type:PROTEIN
Mol. Mass.:66377.32
Organism:Mus musculus
Description:ChEMBL_877992
Residue:602
Sequence:
MRSMRALQNALSRAGSHGRRGGWGHPSRGPLLGRGVRYYLGEAAAQGRGTPHSHQPQHSD
HDASHSGMLPRLGDLLFYTIAEGQERIPIHKFTTALKATGLQTSDPRLQDCMSKMQRMVQ
ESSSGGLLDRELFQKCVSSNIVLLTQAFRKKFVIPDFEEFTGHVDRIFEDAKEPTGGKVA
AYIPHLAKSNPDLWGVSLCTVDGQRHSVGHTKIPFCLQSCVKPLTYAISVSTLGTDYVHK
FVGKEPSGLRYNKLSLNEEGIPHNPMVNAGAIVVSSLIKMDCNKAEKFDFVLQYLNKMAG
NEFMGFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESG
SVMAATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGA
ILLVVPNVMGMMCLSPPLDKLGNSQRGINFCQKLVSLFNFHNYDNLRHCARKLDPRREGG
EVRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIE
ACKVNPFVKDRWGNIPLDDAVQFNHLEVVKLLQDYHDSYLLSETQAEAAAETLSKENLES
MV
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  Blast E-value cutoff:
BDBM108460
n/a
NameBDBM108460
Synonyms:CHEMBL2178393 | US11191732, Example 1 | US8604016, 17 | US9938267, Cmpd ID 17
TypeSmall organic molecule
Emp. Form.C16H18N6OS3
Mol. Mass.406.549
SMILESNc1nnc(CCSCCc2nnc(NC(=O)Cc3ccccc3)s2)s1
Structure
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