Reaction Details | |||
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Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Ligand | BDBM50400148 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_878466 (CHEMBL2187380) | ||
IC50 | 21±n/a nM | ||
Citation | Goldberg, FW; Leach, AG; Scott, JS; Snelson, WL; Groombridge, SD; Donald, CS; Bennett, SN; Bodin, C; Gutierrez, PM; Gyte, AC Free-Wilson and structural approaches to co-optimizing human and rodent isoform potency for 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors. J Med Chem55:10652-61 (2012) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
11-beta-hydroxysteroid dehydrogenase 1 | |||
Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 32409.16 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P28845 | ||
Residue: | 292 | ||
Sequence: |
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BDBM50400148 | |||
n/a | |||
Name | BDBM50400148 | ||
Synonyms: | CHEMBL2179457 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H34N4O3 | ||
Mol. Mass. | 426.5518 | ||
SMILES | O[C@@]12CC3CC(C1)[C@H](NC(=O)c1cnc(N[C@@H]4CCOC4)nc1C1CCCC1)C(C3)C2 |r,wU:7.8,wD:1.0,16.16,TLB:0:1:7:29.3.4,8:7:6.30.1:29.3.4,8:7:4:6.1.2,THB:0:1:7.28.29:4,2:1:7:29.3.4,2:3:7:6.30.1,30:28:4:6.1.2,30:1:7.28.29:4,(15.88,-39.27,;14.35,-39.26,;13.3,-38.14,;11.89,-38.68,;11.24,-39.95,;12.27,-41.03,;13.57,-40.47,;12.28,-42.77,;10.94,-43.55,;9.61,-42.78,;9.6,-41.24,;8.28,-43.56,;6.94,-42.79,;5.61,-43.57,;5.61,-45.11,;4.28,-45.88,;2.94,-45.11,;1.53,-45.73,;.5,-44.58,;1.27,-43.25,;2.78,-43.57,;6.95,-45.88,;8.28,-45.11,;9.62,-45.88,;9.78,-47.4,;11.29,-47.72,;12.06,-46.39,;11.02,-45.24,;13.08,-41.45,;11.91,-40.12,;14.49,-40.88,)| | ||
Structure |