Reaction Details | |||
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Target | 17-beta-hydroxysteroid dehydrogenase type 1 | ||
Ligand | BDBM50400136 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_878460 (CHEMBL2187374) | ||
IC50 | >35000±n/a nM | ||
Citation | Goldberg, FW; Leach, AG; Scott, JS; Snelson, WL; Groombridge, SD; Donald, CS; Bennett, SN; Bodin, C; Gutierrez, PM; Gyte, AC Free-Wilson and structural approaches to co-optimizing human and rodent isoform potency for 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors. J Med Chem55:10652-61 (2012) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
17-beta-hydroxysteroid dehydrogenase type 1 | |||
Name: | 17-beta-hydroxysteroid dehydrogenase type 1 | ||
Synonyms: | 17-beta-HSD 1 | 17-beta-Hydroxysteroid Dehydrogenase 1 (17-beta-HSD1) | 17-beta-hydroxysteroid dehydrogenase type 1 | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | DHB1_HUMAN | E17KSR | E2DH | EDH17B1 | EDH17B2 | EDHB17 | Estradiol 17-beta-dehydrogenase 1 | Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1) | HSD17B1 | Placental 17-beta-hydroxysteroid dehydrogenase | SDR28C1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 34945.13 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P14061 | ||
Residue: | 328 | ||
Sequence: |
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BDBM50400136 | |||
n/a | |||
Name | BDBM50400136 | ||
Synonyms: | CHEMBL2179452 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H34N4O3 | ||
Mol. Mass. | 426.5518 | ||
SMILES | O[C@@]12CC3CC(C1)[C@H](NC(=O)c1cnc(NC4CCOCC4)nc1C1CCC1)C(C3)C2 |r,wU:7.8,wD:1.0,TLB:0:1:7:29.3.4,8:7:6.30.1:29.3.4,8:7:4:6.1.2,THB:0:1:7.28.29:4,2:1:7:29.3.4,2:3:7:6.30.1,30:28:4:6.1.2,30:1:7.28.29:4,(73.77,-13.85,;72.24,-13.84,;71.19,-12.72,;69.78,-13.26,;69.13,-14.53,;70.16,-15.61,;71.46,-15.06,;70.17,-17.35,;68.84,-18.14,;67.5,-17.37,;67.5,-15.83,;66.17,-18.15,;64.83,-17.38,;63.5,-18.15,;63.5,-19.7,;62.16,-20.46,;60.83,-19.7,;60.84,-18.16,;59.52,-17.38,;58.17,-18.15,;58.17,-19.69,;59.51,-20.47,;64.83,-20.47,;66.17,-19.7,;67.51,-20.46,;67.9,-21.95,;69.39,-21.55,;68.99,-20.06,;70.97,-16.03,;69.8,-14.7,;72.38,-15.47,)| | ||
Structure |