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Target11-beta-hydroxysteroid dehydrogenase type 2
LigandBDBM50400147
Substrate/Competitorn/a
Meas. Tech.ChEMBL_878461 (CHEMBL2187375)
IC50>30000±n/a nM
Citation Goldberg, FWLeach, AGScott, JSSnelson, WLGroombridge, SDDonald, CSBennett, SNBodin, CGutierrez, PMGyte, AC Free-Wilson and structural approaches to co-optimizing human and rodent isoform potency for 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors. J Med Chem55:10652-61 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
11-beta-hydroxysteroid dehydrogenase type 2
Name:11-beta-hydroxysteroid dehydrogenase type 2
Synonyms:11-DH2 | 11-beta-HSD2 | 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 2 | 11-beta-hydroxysteroid dehydrogenase type 2 | 11-beta-hydroxysteroid dehydrogenase type 2 (11-beta-HSD2) | Corticosteroid 11-beta-dehydrogenase isozyme 2 | DHI2_HUMAN | HSD11B2 | HSD11K | NAD-dependent 11-beta-hydroxysteroid dehydrogenase | SDR9C3
Type:Enzyme
Mol. Mass.:44141.72
Organism:Homo sapiens (Human)
Description:Purified recombinant human 11beta-HSD2.
Residue:405
Sequence:
MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAV
LAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPG
AIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELS
PVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVA
LLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYI
EHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRR
RFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR
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  Blast E-value cutoff:
BDBM50400147
n/a
NameBDBM50400147
Synonyms:CHEMBL2179014
TypeSmall organic molecule
Emp. Form.C24H34N4O3
Mol. Mass.426.5518
SMILESO[C@@]12CC3CC(C1)[C@H](NC(=O)c1cnc(N[C@H]4CCOC4)nc1C1CCCC1)C(C3)C2 |r,wU:7.8,16.16,wD:1.0,TLB:0:1:7:29.3.4,8:7:6.30.1:29.3.4,8:7:4:6.1.2,THB:0:1:7.28.29:4,2:1:7:29.3.4,2:3:7:6.30.1,30:28:4:6.1.2,30:1:7.28.29:4,(33.95,-38.8,;32.42,-38.79,;31.38,-37.67,;29.96,-38.21,;29.31,-39.49,;30.34,-40.56,;31.64,-40.01,;30.35,-42.31,;29.02,-43.08,;27.68,-42.32,;27.68,-40.78,;26.35,-43.09,;25.02,-42.33,;23.69,-43.1,;23.69,-44.64,;22.35,-45.41,;21.02,-44.64,;19.61,-45.27,;18.58,-44.13,;19.35,-42.79,;20.86,-43.11,;25.02,-45.41,;26.36,-44.64,;27.69,-45.41,;27.86,-46.94,;29.37,-47.26,;30.13,-45.92,;29.1,-44.78,;31.15,-40.98,;29.98,-39.66,;32.56,-40.42,)|
Structure
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