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Target11-beta-hydroxysteroid dehydrogenase 1
LigandBDBM50400140
Substrate/Competitorn/a
Meas. Tech.ChEMBL_878465 (CHEMBL2187379)
IC50 20±n/a nM
Citation Goldberg, FWLeach, AGScott, JSSnelson, WLGroombridge, SDDonald, CSBennett, SNBodin, CGutierrez, PMGyte, AC Free-Wilson and structural approaches to co-optimizing human and rodent isoform potency for 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors. J Med Chem55:10652-61 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
11-beta-hydroxysteroid dehydrogenase 1
Name:11-beta-hydroxysteroid dehydrogenase 1
Synonyms:11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | 11beta-HSD1A | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_MOUSE | Hsd11 | Hsd11b1
Type:Enzyme
Mol. Mass.:32369.70
Organism:Mus musculus (mouse)
Description:P50172
Residue:292
Sequence:
MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAH
VVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNH
ITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMI
APYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEE
CALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
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  Blast E-value cutoff:
BDBM50400140
n/a
NameBDBM50400140
Synonyms:CHEMBL2179448
TypeSmall organic molecule
Emp. Form.C22H32N4O3
Mol. Mass.400.5145
SMILESCC(C)(CO)Nc1ncc(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)c(n1)C1CC1 |r,wU:13.12,wD:20.21,TLB:21:20:13:17.16.15,12:13:23.19.20:17.16.15,12:13:15:23.20.22,THB:21:20:13.18.17:15,22:20:13:17.16.15,22:16:13:23.19.20,19:18:15:23.20.22,19:20:13.18.17:15,(65.64,-8.07,;66.42,-9.41,;66.82,-7.92,;65.09,-10.18,;63.76,-9.41,;67.76,-10.18,;69.09,-9.42,;69.09,-7.87,;70.42,-7.1,;71.76,-7.86,;73.09,-7.09,;73.08,-5.55,;74.42,-7.85,;75.75,-7.08,;75.75,-5.34,;74.71,-4.26,;75.36,-2.99,;75.39,-4.43,;76.55,-5.75,;77.97,-5.19,;77.82,-3.56,;79.36,-3.58,;76.78,-2.44,;77.05,-4.78,;71.76,-9.41,;70.42,-10.19,;73.1,-10.18,;73.87,-11.52,;74.64,-10.18,)|
Structure
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