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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Ligand | BDBM50400162 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_878466 (CHEMBL2187380) | ||
| IC50 | 19±n/a nM | ||
| Citation |  Goldberg, FW; Leach, AG; Scott, JS; Snelson, WL; Groombridge, SD; Donald, CS; Bennett, SN; Bodin, C; Gutierrez, PM; Gyte, AC Free-Wilson and structural approaches to co-optimizing human and rodent isoform potency for 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors. J Med Chem55:10652-61 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 11-beta-hydroxysteroid dehydrogenase 1 | |||
| Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 32409.16 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P28845 | ||
| Residue: | 292 | ||
| Sequence: |
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| BDBM50400162 | |||
| n/a | |||
| Name | BDBM50400162 | ||
| Synonyms: | CHEMBL2179440 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H36N4O3 | ||
| Mol. Mass. | 428.5676 | ||
| SMILES | CC(C)(O)CNc1ncc(C(=O)N[C@H]2C3CC4CC2C[C@](O)(C4)C3)c(n1)C1CCCC1 |r,wU:13.12,wD:20.21,TLB:21:20:13:17.16.15,12:13:23.19.20:17.16.15,12:13:15:23.20.22,THB:21:20:13.18.17:15,22:20:13:17.16.15,22:16:13:23.19.20,19:18:15:23.20.22,19:20:13.18.17:15,(40.79,-40.02,;41.57,-38.69,;42.33,-40.02,;40.24,-37.92,;42.91,-37.92,;44.24,-38.69,;45.57,-37.92,;45.57,-36.38,;46.9,-35.61,;48.24,-36.37,;49.57,-35.59,;49.56,-34.05,;50.91,-36.36,;52.24,-35.58,;52.23,-33.84,;51.2,-32.76,;51.85,-31.49,;51.87,-32.93,;53.04,-34.26,;54.45,-33.69,;54.31,-32.07,;55.84,-32.08,;53.26,-30.95,;53.53,-33.28,;48.24,-37.92,;46.91,-38.69,;49.58,-38.69,;49.74,-40.21,;51.25,-40.53,;52.02,-39.2,;50.99,-38.05,)| | ||
| Structure | 
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