| Reaction Details |
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 | Report a problem with these data |
| Target | Complement factor D |
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| Ligand | BDBM50400275 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_872411 (CHEMBL2188699) |
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| IC50 | 3±n/a nM |
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| Citation |  Abdel-Magid, AF Factor D Inhibitors for the Treatment of AMD: Patent Highlight. ACS Med Chem Lett3:781-782 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Complement factor D |
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| Name: | Complement factor D |
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| Synonyms: | Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D |
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| Type: | Protein |
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| Mol. Mass.: | 27039.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00746 |
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| Residue: | 253 |
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| Sequence: | MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQW
VLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQL
SEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCN
RRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTR
VASYAAWIDSVLA
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| BDBM50400275 |
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| n/a |
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| Name | BDBM50400275 |
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| Synonyms: | CHEMBL2180766 | US9085555, 127 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H31ClFN5O5 |
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| Mol. Mass. | 584.038 |
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| SMILES | CC(C)(C)OC(=O)Cc1ccc2c(NC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)NCc3cccc(Cl)c3F)cn(C(N)=O)c2c1 |r| |
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| Structure | 
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