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TargetNAD-dependent protein deacetylase sirtuin-1
LigandBDBM50309829
Substrate/Competitorn/a
Meas. Tech.ChEMBL_876636 (CHEMBL2182361)
IC50 40300±n/a nM
Citation Rotili, DTarantino, DNebbioso, APaolini, CHuidobro, CLara, EMellini, PLenoci, APezzi, RBotta, GLahtela-Kakkonen, MPoso, ASteinkühler, CGallinari, PDe Maria, RFraga, MEsteller, MAltucci, LMai, A Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells. J Med Chem55:10937-47 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
NAD-dependent protein deacetylase sirtuin-1
Name:NAD-dependent protein deacetylase sirtuin-1
Synonyms:NAD-Dependent Deacetylase Sirtuin-1 | NAD-dependent deacetylase sirtuin 1 | NAD-dependent protein deacetylase sirtuin-1 (SIRT1) | SIR1_HUMAN | SIR2-like protein 1 | SIR2L1 | SIRT1 | Sirtuin 1 (SIRT1) | Sirtuin-1 (SIRT1) | hSIR2
Type:Developmental protein; hydrolase
Mol. Mass.:81626.66
Organism:Homo sapiens (Human)
Description:n/a
Residue:747
Sequence:
MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREV
PAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNL
YDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRP
RIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDI
NTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIE
YFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRII
QCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPE
QFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLG
DCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSS
PERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDL
KNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSD
SEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTD
GDDQEAINEAISVKQEVTDMNYPSNKS
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BDBM50309829
n/a
NameBDBM50309829
Synonyms:1-((3-(2-phenylpropylthio)phenylimino)methyl)naphthalen-2-ol | CHEMBL596656
TypeSmall organic molecule
Emp. Form.C26H23NOS
Mol. Mass.397.532
SMILESCC(CSc1cccc(c1)\N=C\c1c(O)ccc2ccccc12)c1ccccc1
Structure
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